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Trends Biochem Sci. 1995 May;20(5):181-7.

The dynamic role of palmitoylation in signal transduction.

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  • 1Division of Biochemistry and Molecular Biology, University of Glasgow, UK.


Guanine nucleotide binding protein (G protein)-linked receptors, the alpha-subunits of heterotrimeric G proteins and members of the Src family of nonreceptor tyrosine kinases are among many polypeptides that are posttranslationally modified by the addition of palmitate, a long-chain fatty acid. Attachment of palmitate to these proteins is dynamic and may be regulated by their activation. The presence of palmitate appears to play a key role in the membrane localization of either the entire polypeptide or parts of it, and may regulate the interactions of these polypeptides with other proteins.

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