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The dynamic role of palmitoylation in signal transduction.
Division of Biochemistry and Molecular Biology, University of Glasgow, UK.
Guanine nucleotide binding protein (G protein)-linked receptors, the alpha-subunits of heterotrimeric G proteins and members of the Src family of nonreceptor tyrosine kinases are among many polypeptides that are posttranslationally modified by the addition of palmitate, a long-chain fatty acid. Attachment of palmitate to these proteins is dynamic and may be regulated by their activation. The presence of palmitate appears to play a key role in the membrane localization of either the entire polypeptide or parts of it, and may regulate the interactions of these polypeptides with other proteins.
PMID: 7610481 [PubMed - indexed for MEDLINE]
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Cited by 46 PubMed Central articles
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Palmitoylation of POTE family proteins for plasma membrane targeting.
Das S, Ise T, Nagata S, Maeda H, Bera TK, Pastan I.
Biochem Biophys Res Commun. 2007 Nov 23; 363(3):751-6. Epub 2007 Sep 21.
[Biochem Biophys Res Commun. 2007]
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ReviewAssembly and trafficking of heterotrimeric G proteins.
Marrari Y, Crouthamel M, Irannejad R, Wedegaertner PB.
Biochemistry. 2007 Jul 3; 46(26):7665-77. Epub 2007 Jun 9.
[Biochemistry. 2007]
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Genetic modifiers of Drosophila palmitoyl-protein thioesterase 1-induced degeneration.
Buff H, Smith AC, Korey CA.
Genetics. 2007 May; 176(1):209-20. Epub 2007 Apr 3.
[Genetics. 2007]
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