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Cytogenet Cell Genet. 1995;71(1):99-103.

Mitochondrial DNA mutations in normal and tumor tissues from breast cancer patients.

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  • 1Instituto Multidisciplinario de Biologia Celular, La Plata, Argentina.

Abstract

We have characterized the mtDNA in normal and breast cancer tissues from seven patients. Both types of tissue showed point mutation heteroplasmies and extensive deletions of the mtDNA. The analysis of these polymorphisms allowed us to infer the mtDNA composition of the breast cell that underwent malignant transformation.

PMID:
7606938
[PubMed - indexed for MEDLINE]
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