Neurosci Lett. 1995 Apr 7;189(1):43-6.

Awakening properties of modafinil without paradoxical sleep rebound: comparative study with amphetamine in the rat.

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Department of Experimental Medicine, Claude Bernard University, Lyon, France.

Abstract

We have studied the effect of modafinil and amphetamine, two waking drugs, on the sleep-wake cycle of Sprague-Dawley rat. Both modafinil (64 or 128 mg/kg) and amphetamine (2.5 or 5 mg/kg) cause a dose dependent increase in wakefulness. However, amphetamine wakefulness is followed by a paradoxical sleep rebound on the injection day, whereas modafinil does not produce this effect. In modafinil-treated rats, the sleep pattern on the post-injection day is similar to that of controls, while that of amphetamine-treated rats is modified.

PMID:: 7603622; [PubMed - indexed for MEDLINE]

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