The NACP/synuclein gene: chromosomal assignment and screening for alterations in Alzheimer disease

Genomics. 1995 Mar 20;26(2):254-7. doi: 10.1016/0888-7543(95)80208-4.

Abstract

The major component of the vascular and plaque amyloid deposits in Alzheimer disease is the amyloid beta peptide (A beta). A second intrinsic component of amyloid, the NAC (non-A beta component of amyloid) peptide, has recently been identified, and its precursor protein was named NACP. A computer homology search allowed us to establish that the human NACP gene was homologous to the rat synuclein gene. We mapped the NACP/synuclein gene to chromosome 4 and cloned three alternatively spliced transcripts in lymphocytes derived from a normal subject. We analyzed by RT-PCR and direct sequencing the entire coding region of the NACP/synuclein gene in a group of patients with familial early onset Alzheimer disease. No mutation was found in 26 unrelated patients. Further studies are required to investigate the implication of the NACP/synuclein gene in Alzheimer disease.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age of Onset
  • Alzheimer Disease / epidemiology
  • Alzheimer Disease / genetics*
  • Amino Acid Sequence
  • Amyloid / genetics*
  • Animals
  • Base Sequence
  • Cell Line, Transformed
  • Chromosome Mapping
  • Chromosomes, Human, Pair 4*
  • DNA Mutational Analysis
  • Disease Susceptibility
  • Genes
  • Humans
  • Hybrid Cells
  • Lymphocytes / metabolism
  • Molecular Sequence Data
  • Nerve Tissue Proteins / genetics*
  • Protein Precursors / genetics*
  • Rats / genetics
  • Synucleins

Substances

  • Amyloid
  • Nerve Tissue Proteins
  • Protein Precursors
  • Synucleins

Associated data

  • GENBANK/L36674
  • GENBANK/L36675