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Genes Dev. 1995 Jun 15;9(12):1543-57.

A developmentally regulated chromosomal origin of replication uses essential transcription elements.

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  • 1Department of Developmental Biology, Beckman Center, Stanford University School of Medicine, California 94305-5427, USA.


Only one of the two chromosomes in the asymmetric Caulobacter predivisional cell initiates replication in the progeny cells. Transcription from a strong promoter within the origin occurs uniquely from the replication-competent chromosome at the stalked pole of the predivisional cell. This regulated promoter has an unusual sequence organization, and transcription from this promoter is essential for regulated (cell type-specific) replication. Our analysis defines a new class of bacterial origins and suggests a coupling between transcription and replication that is consistent with the phylogenetic relationship of Caulobacter to the ancestral mitochondrion.

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