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Pharmacology of cannabinoid receptors.

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  • 1Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, Missouri 63104, USA.

Abstract

Two subtypes of cannabinoid receptors, CB1 and CB2, have been described to date, although future investigations may elucidate other receptors. The actions of cannabimimetic agents via CB1 receptors in brain are mediated by GI/O to inhibit adenylate cyclase and Ca2+ channels. Little is known about signal transduction mechanisms utilized by CB2 receptors. Three classes of agonist ligands regulate cannabinoid receptors: cannabinoid, aminoalkyl-indole, and eicosanoid derivatives. Cannabinoid receptors produce analgesia and modify cognition, memory, locomotor activity, and endocrine functions in mammals.

PMID:
7598509
[PubMed - indexed for MEDLINE]
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