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Leuk Res. 1995 Jun;19(6):361-5.

Epidemiologic perspectives on myelodysplastic syndromes and leukemia.

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  • 1Department of Epidemiology, School of Public Health, University of Alabama at Birmingham 35294-0008, USA.


The ICD classification of the myelodysplastic syndromes (MDS), and the four main features of the descriptive epidemiology of the condition are discussed. MDS is: (1) a rare disease; which may be, (2) on the increase; (3) which primarily affects the elderly; and (4) which predominantly affects men. We reviewed four causal models pertaining to the relationship between MDS and leukemia. These models may be described as: (1) non-biological correlates; (2) biological correlates; (3) early phase; and (4) interactive cause. Each model is described and the evidence in support of or against each is presented.

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