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J Gen Virol. 1995 Nov;76 ( Pt 11):2869-73.

In vivo induction of apoptosis by influenza virus.

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  • 1Department of Microbiology, Fukui Medical School, Japan.


Intranasal exposure of mice to influenza virus led to cell death in bronchial/bronchiolar epithelial cells, alveolar cells and lymphoid cells. These cells displayed fragmentation of nuclei and chromatin condensation. Nick end-labelling of DNA in situ confirmed that such apoptotic cells had fragmented DNA. These results suggest that the influenza virus induces apoptosis in vivo.

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