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    J Bacteriol. 1995 Nov;177(22):6688-92.

    Cloning and characterization of the Streptomyces peucetius dnrQS genes encoding a daunosamine biosynthesis enzyme and a glycosyl transferase involved in daunorubicin biosynthesis.

    Otten SL, Liu X, Ferguson J, Hutchinson CR.

    Source

    School of Pharmacy, University of Wisconsin, Madison 53706, USA.

    Abstract

    The dnrQS genes from the daunorubicin producer Streptomyces peucetius were characterized by DNA sequencing, complementation analysis, and gene disruption. The dnrQ gene is required for daunosamine biosynthesis, and dnrS appears to encode a glycosyltransferase for the addition of the 2,3,6-trideoxy-3-aminohexose, daunosamine, to epsilon-rhodomycinone.

    PMID:
    7592454
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC177529
    Free PMC Article

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