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Infect Immun. 1995 Nov;63(11):4550-2.

Giardicidal activity of lactoferrin and N-terminal peptides.

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  • 1Division of Infectious Diseases, University of California at San Diego 92103-8416, USA.

Abstract

Human and bovine lactoferrins and their derived N-terminal peptides were giardicidal in vitro. Fe3+, but not Fe2+, protected trophozoites from both native lactoferrin and peptides, although the latter lack iron-binding sites. Other divalent metal ions protected only against native lactoferrin. Log-phase cells were more resistant to killing than stationary-phase cells. These studies suggest that lactoferrin, especially in the form of the N-terminal peptides, may be an important nonimmune component of host mucosal defenses against Giardia lamblia.

PMID:
7591103
[PubMed - indexed for MEDLINE]
PMCID:
PMC173652
Free PMC Article
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