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Fertil Steril. 1995 Nov;64(5):995-8.

Outcome of ovum donation in Turner's syndrome patients.

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  • 1Department of Obstetrics and Gynecology, University of Toronto, Ontario, Canada.

Abstract

OBJECTIVE:

To determine whether there is a difference in the pregnancy rate in women with Turner's syndrome (45,X) in an ovum donation program compared with women with other causes of premature ovarian failure.

DESIGN:

Retrospective chart review of women with Turner's syndrome (n = 11) and premature ovarian failure (n = 38) in a donor ovum program using variable dose and duration of E2 replacement therapy for endometrial preparation and using only transvaginal ultrasonographic assessment of endometrial response before ET.

RESULTS:

The pregnancy rates in Turner's syndrome patients and control subjects were 27% and 25%, respectively. Pregnancy rates were higher in the first cycle than in subsequent cycles for both groups (40% versus 8%).

CONCLUSIONS:

Turner's syndrome patients given a variable dose of estrogen, for endometrial preparation, with response assessed exclusively by transvaginal ultrasonography demonstrated pregnancy rates equal to patients with other causes of premature ovarian failure.

PMID:
7589649
[PubMed - indexed for MEDLINE]
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