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FEBS Lett. 1995 Nov 6;374(3):317-22.

Homodimerization and intermolecular tyrosine phosphorylation of the Tyk-2 tyrosine kinase.

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  • 1Department of Pathology, University of Tennessee, Memphis 88163, USA.

Abstract

The Jak kinases and Stat transcription factors play a major role in signaling of various cytokines including IFN alpha. In this report we show a ligand-independent interaction between Tyk-2 and Jak-1 kinases. We also demonstrate that the Tyk-2 kinase forms a homodimer that has the ability to undergo intermolecular tyrosine phosphorylation. The formation of the Tyk-2 homodimer is independent of both tyrosine phosphorylation and the presence of the tyrosine kinase domain.

PMID:
7589562
[PubMed - indexed for MEDLINE]
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