Send to:

Choose Destination
See comment in PubMed Commons below
FEBS Lett. 1995 Nov 6;374(3):317-22.

Homodimerization and intermolecular tyrosine phosphorylation of the Tyk-2 tyrosine kinase.

Author information

  • 1Department of Pathology, University of Tennessee, Memphis 88163, USA.


The Jak kinases and Stat transcription factors play a major role in signaling of various cytokines including IFN alpha. In this report we show a ligand-independent interaction between Tyk-2 and Jak-1 kinases. We also demonstrate that the Tyk-2 kinase forms a homodimer that has the ability to undergo intermolecular tyrosine phosphorylation. The formation of the Tyk-2 homodimer is independent of both tyrosine phosphorylation and the presence of the tyrosine kinase domain.

[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Write to the Help Desk