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FEBS Lett. 1995 Oct 16;373(3):265-8.

Interaction of peptides derived from the Fas ligand with the Fyn-SH3 domain.

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  • 1Institute of Biochemistry, University of Lausanne, Epalinges, Switzerland.

Abstract

Interaction of the widely expressed Fas with its membrane-bound ligand (FasL) leads to rapid cell death via apoptosis. To avoid pathological tissue damage, the activity of FasL requires tight regulation. Here, we report that the Src homology 3 (SH3) domain of Fyn binds to the proline-rich cytoplasmic region of FasL. Binding of the SH3 domain occurs between amino acid residues 44-71 which contains several potential SH3 interaction sites. This binding is specific, as SH3 domains of Lck, Grb2 and ras-GAP bind only weakly or not at all. We suggest that FasL activity may be modulated by SH3 domains of the src-like Fyn kinase.

PMID:
7589480
[PubMed - indexed for MEDLINE]
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