Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
EMBO J. 1995 Oct 16;14(20):5016-26.

Two different thresholds of wingless signalling with distinct developmental consequences in the Drosophila midgut.

Author information

  • 1MRC Laboratory of Molecular Biology, Cambridge, UK.

Abstract

Drosophila wingless encodes a Wnt protein which mediates communication between cells. Although wingless protein is secreted from cells, there is debate as to what is the range of wingless action. We examined the function of wingless in the larval midgut, and found that wingless acts at two different thresholds to pattern this tissue. Low wingless levels are required to promote the development of copper cells, highly differentiated midgut cells of the larval midgut that are specified by the homeotic gene labial. High wingless levels repress copper cell development and allow differentiation of an alternative cell type, called large flat cells. These two developmental outcomes reflect labial expression, which is stimulated at low levels and repressed at high levels of wingless signalling. Thus, midgut cells respond differentially to distinct wingless thresholds in terms of both gene control and cellular differentiation.

PMID:
7588630
[PubMed - indexed for MEDLINE]
PMCID:
PMC394605
Free PMC Article

LinkOut - more resources

Full Text Sources

Molecular Biology Databases

PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for PubMed Central
    Loading ...
    Write to the Help Desk