Eight-week old male quails were fed with high-fat fodder supplemented by 20 milliliters of coconut juice daily for each one for 12 weeks. Results showed coconut juice could increase their serum high density lipoprotein cholesterol levels by 46.2% and reduce their index of atherosclerosis by 41.1% and liver total cholesterol levels by 26.3% in quails, all with a P-value of less than 0.01, as compared in those with high-fat fodder only. Coconut juice could inhibit the formation of atherosclerosis in animals obviously. Coconut juice, as a kind of natural and nutritious drink with an action of keeping-fit, can play certain roles in preventing from hyperlipidemia and atherosclerosis with a dose used in animal experiments.