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Semin Immunol. 1995 Apr;7(2):75-82.

NK cell recognition of major histocompatibility complex class I molecules.

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  • 1Department of Human Immunology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304, USA.

Abstract

Interactions between membrane receptors on NK cells and major histocompatibility complex (MHC) class I molecules on target cells inhibit NK cell-mediated cytotoxicity. In the mouse, receptors encoded by genes of the Ly-49 family bind certain polymorphic H-2 molecules and prevent lysis of normal hematopoietic cell targets. While a human homolog of Ly-49 has not been identified as yet, two structurally distinct NK cell-associated membrane glycoproteins, NKB1 and p58, have been implicated in the recognition of polymorphic HLA-B and HLA-C molecules, respectively. Recent studies indicate that human NK cell clones express multiple receptors for HLA class I molecules and suggest that these receptors may operate independently when expressed in a single NK cell clone.

PMID:
7579197
[PubMed - indexed for MEDLINE]
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