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Arch Oral Biol. 1995 Jul;40(7):589-95.

Instruction by retinoic acid of incisor morphology in the mouse embryonic mandible.

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  • 1Department of Orthodontics, School of Dentistry, Oregon Health Sciences University Portland 97201, USA.


Endogenous retinoids are present in the embryonic mouse mandible and reach a peak in concentration at the time of the formation of the dental lamina. All-trans retinoic acid is present in a 10-fold higher concentration in the future incisor region of the mouse embryonic mandible at day 11.5. It was found here that exogenous all-trans retinoic acid has pleiotropic effects on the pattern of odontogenesis when applied before the formation of the dental lamina. These effects include a change in the pattern of the dental lamina, supernumerary buds and incisors in the diastema region, and replacement of molars with incisors in the molar region. Thus retinoic acid appears to instruct incisor morphology in the mouse embryonic mandible.

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