Identification of the human neuronal nicotinic cho...[Somat Cell Mol Genet. 1995]

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1: Somat Cell Mol Genet. 1995 Mar;21(2):147-50.Links

Identification of the human neuronal nicotinic cholinergic alpha 2 receptor locus, (CHRNA2), within an 8p21 mapped locus, by sequence homology with rat DNA.

Wood S, Schertzer M, Yaremko ML.

Department of Medical Genetics, University of British Columbia, Vancouver, Canada.

We have identified a cosmid, at the D8S131 locus, that shows sequence homology with exon 2 of the rat gene for the neuronal nicotinic acetylcholine receptor alpha 2 subunit. A 357-bp sequence surrounding a rare cutter AscI site contains a 152-bp region of homology. The human CHRNA2 gene is therefore positioned at the D8S131 locus, which has been mapped to 8p21.

PMID: 7570187 [PubMed - indexed for MEDLINE]

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[Genomics. 1995]
ReviewThe nicotinic acetylcholine receptor gene family: structure of nicotinic receptors from muscle and neurons and neuronal alpha-bungarotoxin-binding proteins.
Adv Exp Med Biol. 1991; 287:255-78.

[Adv Exp Med Biol. 1991]
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Cited by 1 PubMed Central article

Localization of a gene for benign adult familial myoclonic epilepsy to chromosome 8q23.3-q24.1.
Mikami M, Yasuda T, Terao A, Nakamura M, Ueno S, Tanabe H, Tanaka T, Onuma T, Goto Y, Kaneko S, et al. Am J Hum Genet. 1999 Sep; 65(3):745-51.

[Am J Hum Genet. 1999]

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Identification of the human neuronal nicotinic cholinergic alpha 2 receptor locus, (CHRNA2), within an 8p21 mapped locus, by sequence homology with rat DNA.

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