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T cell awareness of paternal alloantigens during pregnancy.
Tumor Immunology Program, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany.
During pregnancy a semiallogeneic fetus survives despite the presence of maternal T cells specific for paternally inherited histocompatibility antigens. A mouse transgenic for a T cell receptor recognizing the major histocompatibility (MHC) antigen H-2Kb was used to follow the fate of T cells reactive to paternal alloantigens. In contrast to syngeneic and third-party allogeneic pregnancies, mice bearing a Kb-positive conceptus had reduced numbers of Kb-reactive T cells and accepted Kb-positive tumor grafts. T cell phenotype and responsiveness were restored after delivery. Thus, during pregnancy maternal T cells acquire a transient state of tolerance specific for paternal alloantigens.
PMID: 7570020 [PubMed - indexed for MEDLINE]
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Cited by 29 PubMed Central articles
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Syngeneic immune-dependent abortions in mice suggest paternal alloantigen-independent mechanisms.
Kundert JA, Sealey AL, Li Y, Capecchi MR, Schmidt EE.
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[Am J Reprod Immunol. 2008]
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ReviewThe fetal allograft revisited: does the study of an ancient invertebrate species shed light on the role of natural killer cells at the maternal-fetal interface?
Lightner A, Schust DJ, Chen YB, Barrier BF.
Clin Dev Immunol. 2008; 2008:631920.
[Clin Dev Immunol. 2008]
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Immunopathology of early pregnancy.
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[Infect Dis Obstet Gynecol. 1997]
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