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Radiother Oncol. 1995 May;35(2):83-90.

Cellular basis of radiation-induced fibrosis.

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  • 1Department of Radiotherapy, Eberhard-Karls-University, Tübingen, Germany.


Fibrosis is a common sequela of both cancer treatment by radiotherapy and accidental irradiation and has been described in many tissues including skin, lung, heart and liver. The underlying mechanisms of the radiation-induced fibrosis still remain to be resolved. In the present review we tried to illustrate the basic cellular mechanisms of radiation-induced fibrosis based on the newest findings arising from molecular radiobiology and cell biology. Based on these findings the cellular mechanism of radiation-induced fibrosis can be seen as a multicellular process involving various interacting cell systems in the target organ resulting in the fibrotic phenotype of the fibroblast/fibrocyte cell system.

[PubMed - indexed for MEDLINE]
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