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Pediatr Clin North Am. 1995 Oct;42(5):1155-69.

Clinical and genetic evidence that juvenile arthritis is not a single disease.

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  • 1Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, USA.


Ample evidence shows that what was formerly called "juvenile rheumatoid arthritis" is not a single disease. At least six separate diseases were included as subgroups or subtypes of juvenile rheumatoid arthritis in other classifications. The clinical and laboratory features that differentiate these diseases are discussed. Genetic differences, primarily within the HLA system but also for T-cell receptor genes are described and correlated with the new clinical classification of arthritis.

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