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- Comment in:
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Nature. 1995 Oct 5;377(6548):387-8.
Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor.
Hörlein AJ,
Näär AM,
Heinzel T,
Torchia J,
Gloss B,
Kurokawa R,
Ryan A,
Kamei Y,
Söderström M,
Glass CK, et al.
Howard Hughes Medical Institute, University of California, San Diego, La Jolla 92093-0648, USA.
Thyroid-hormone and retinoic-acid receptors exert their regulatory functions by acting as both activators and repressors of gene expression. A nuclear receptor co-repressor (N-CoR) of relative molecular mass 270K has been identified which mediates ligand-independent inhibition of gene transcription by these receptors, suggesting that the molecular mechanisms of repression by thyroid-hormone and retinoic-acid receptors are analogous to the co-repressor-dependent transcriptional inhibitory mechanisms of yeast and Drosophila.
PMID: 7566114 [PubMed - indexed for MEDLINE]
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Cited by over 100 PubMed Central articles
Patient Drug Information
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Thyroid (Armour® Thyroid)
Thyroid is a hormone produced by the body. When taken correctly, thyroid is used to treat the symptoms of hypothyroidism (a condition where the thyroid gland does not produce enough thyroid hormone). Symptoms of hypothyr...
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Liothyronine (Cytomel® )
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