Linkage analyses of the MODY3 locus on chromosome 12q with late-onset NIDDM

Diabetes. 1995 Oct;44(10):1243-7. doi: 10.2337/diab.44.10.1243.

Abstract

Non-insulin-dependent diabetes mellitus (NIDDM) is a clinically and genetically heterogeneous disorder. Maturity-onset diabetes of the young (MODY), an autosomal dominant form of NIDDM, has been used as a model for genetic studies of NIDDM. We recently reported linkage between markers on chromosome 12q and diabetes in 25% of our French MODY families. To evaluate if this gene is also implicated in late-onset NIDDM, we performed linkage studies between two markers of the MODY region and diabetes in 172 families with late-onset NIDDM. Both parametric and nonparametric methods were used in a total of 600 affected sib-pairs. Linkage was rejected in this population by all methods, implying that the MODY gene on chromosome 12q is not a major gene for late-onset NIDDM in this population. However, we cannot exclude a modifying role in a polygenic disorder or an important role in some families.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Age Factors
  • Age of Onset
  • Base Sequence
  • Chromosome Mapping*
  • Chromosomes, Human, Pair 12*
  • DNA Primers
  • Diabetes Mellitus, Type 2 / genetics*
  • Diabetes Mellitus, Type 2 / physiopathology
  • Female
  • Genes, Dominant
  • Genetic Linkage*
  • Humans
  • Male
  • Middle Aged
  • Molecular Sequence Data
  • Parents
  • Polymerase Chain Reaction
  • Sex Characteristics

Substances

  • DNA Primers