Novel 2-amino-1,4-dihydropyridine calcium antagoni...[Chem Pharm Bull (Tokyo). 1995]

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1: Chem Pharm Bull (Tokyo). 1995 May;43(5):788-96.Links

Novel 2-amino-1,4-dihydropyridine calcium antagonists. I. Synthesis and antihypertensive effects of 2-amino-1,4-dihydropyridine derivatives having nitroxy-alkoxycarbonyl groups at 3- and/or 5-position.

Kobayashi T, Inoue T, Kita Z, Yoshiya H, Nishino S, Oizumi K, Kimura T.

Pharmaceutical Research Department, Ube Laboratory, Ube Industries, Ltd., Yamaguchi, Japan.

Novel 2-amino-1,4-dihydropyridine derivatives, which contain nitroxy-alkoxycarbonyl groups at the 3- and/or 5-position, were synthesized and their pharmaceutical effect was evaluated in spontaneously hypertensive rats. The structure-activity relationships are discussed in terms of potency, onset-rapidity, and duration of antihypertensive activity. Remarkably prolonged duration of antihypertensive action was observed when a tertiary amino group was introduced on either side of an ester chain.

PMID: 7553966 [PubMed - indexed for MEDLINE]

Novel 2-amino-1,4-dihydropyridine calcium antagonists. II. Synthesis and antihypertensive effects of 2-amino-1,4-dihydropyridine derivatives having N,N-dialkylaminoalkoxycarbonyl groups at 3- and/or 5-position.
Chem Pharm Bull (Tokyo). 1995 May; 43(5):797-817.

[Chem Pharm Bull (Tokyo). 1995]
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Novel 2-amino-1,4-dihydropyridine calcium antagonists. I. Synthesis and antihypertensive effects of 2-amino-1,4-dihydropyridine derivatives having nitroxy-alkoxycarbonyl groups at 3- and/or 5-position.

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