Send to:

Choose Destination
See comment in PubMed Commons below
Brain Res. 1995 Jun 5;682(1-2):245-50.

Increased density of mu-opioid receptors in the postmortem brain of suicide victims.

Author information

  • 1Department of Pharmacology, University of the Basque Country, Leioa, Bizkaia, Spain.


The biochemical status of mu-opioid receptors in suicide was evaluated by [3H]DAGO specific binding in postmortem human brains from 15 suicide victims and 15 controls. The density (Bmax) in frontal cortex and thalamus was directly correlated with age. In the frontal cortex and caudate but not in the thalamus of suicide victims the density of mu-opioid receptors was 36-39% higher than in controls. KD values in suicide victims were similar to those in control group (range 1.4-2.2 nM). The results suggest an increase of mu-opioid receptors in suicide associated to some brain areas showing the mu2-opioid receptor subtype.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk