Regulation of immune function by protein tyrosine phosphatases

M Okumura; M L Thomas

doi:10.1016/0952-7915(95)80104-9

Regulation of immune function by protein tyrosine phosphatases

Curr Opin Immunol. 1995 Jun;7(3):312-9. doi: 10.1016/0952-7915(95)80104-9.

Authors

M Okumura¹, M L Thomas

Affiliation

¹ Howard Hughes Medical Institute, Department of Pathology, Washington University School of Medicine, St Louis, MO 63130, USA.

PMID: 7546394
DOI: 10.1016/0952-7915(95)80104-9

Abstract

CD45 is a leukocyte transmembrane protein tyrosine phosphatase that functions in lymphocyte activation by increasing the kinase activity of Src family members. In contrast, an intracellular protein tyrosine phosphatase that contains Src homology 2 domains, SHP, is required to inactivate receptors. Recent studies have examined the mechanisms of interaction and regulation of these enzymes.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

MeSH terms

Animals
Humans
Intracellular Signaling Peptides and Proteins
Leukocyte Common Antigens / immunology*
Mice
Models, Immunological
Protein Tyrosine Phosphatase, Non-Receptor Type 11
Protein Tyrosine Phosphatase, Non-Receptor Type 6
Protein Tyrosine Phosphatases / immunology*
SH2 Domain-Containing Protein Tyrosine Phosphatases
Signal Transduction / immunology
src Homology Domains / immunology

Substances

Intracellular Signaling Peptides and Proteins
Leukocyte Common Antigens
PTPN11 protein, human
PTPN6 protein, human
Protein Tyrosine Phosphatase, Non-Receptor Type 11
Protein Tyrosine Phosphatase, Non-Receptor Type 6
Protein Tyrosine Phosphatases
Ptpn11 protein, mouse
Ptpn6 protein, mouse
SH2 Domain-Containing Protein Tyrosine Phosphatases