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Immunol Today. 1995 Sep;16(9):449-57.

High endothelial venules (HEVs): specialized endothelium for lymphocyte migration.

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  • 1Laboratoire de Biologie Mol├ęculaire Eucaryote (LBME) du CNRS, Toulouse, France.


High endothelial venules (HEVs) are specialized postcapillary venules found in lymphoid tissues that support high levels of lymphocyte extravasation from the blood. Here, Jean-Philippe Girard and Timothy Springer highlight the unique properties of HEV endothelium, discuss the molecular mechanisms controlling HEV specialization and review evidence suggesting that HEVs could play an important role in the pathogenesis of chronic inflammatory diseases.

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