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High endothelial venules (HEVs): specialized endothelium for lymphocyte migration.
Laboratoire de Biologie Moléculaire Eucaryote (LBME) du CNRS, Toulouse, France.
High endothelial venules (HEVs) are specialized postcapillary venules found in lymphoid tissues that support high levels of lymphocyte extravasation from the blood. Here, Jean-Philippe Girard and Timothy Springer highlight the unique properties of HEV endothelium, discuss the molecular mechanisms controlling HEV specialization and review evidence suggesting that HEVs could play an important role in the pathogenesis of chronic inflammatory diseases.
PMID: 7546210 [PubMed - indexed for MEDLINE]
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Cited by 47 PubMed Central articles
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Extravasation of leukocytes in comparison to tumor cells.
Strell C, Entschladen F.
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[Cell Commun Signal. 2008]
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Chiappelli F, Shapshak P, Commins D, Singer E, Minagar A, Oluwadara O, Prolo P, Pellionisz AJ.
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[Bioinformation. 2008]
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Lundberg IE, Grundtman C.
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[Arthritis Res Ther. 2008]
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