The genomic structure encoding human initiation factor eIF-5A

Gene. 1994 Jul 8;144(2):249-52. doi: 10.1016/0378-1119(94)90385-9.

Abstract

A genomic clone encoding the human eukaryotic initiation factor 5A (eIF-5A) was isolated and its entire nucleotide sequence was determined. The whole eIF-5A coding region is not interrupted by introns. The functional eIF-5A gene is highly homologous to the corresponding complementary DNA. One single 1.4-kb transcript thereof is expressed in human cell lines. Furthermore, we also isolated and sequenced two additional eIF-5A-related sequences which are, by expression and sequence analyses, identified as pseudogenes of the functional eIF-5A. The sequence homology between these pseudogenes and the functional eIF-5A is 71 and 87%.

MeSH terms

  • Base Sequence
  • Cosmids
  • DNA, Complementary
  • Eukaryotic Translation Initiation Factor 5A
  • HeLa Cells
  • Humans
  • Introns
  • Molecular Sequence Data
  • Peptide Initiation Factors / genetics*
  • RNA, Messenger / genetics
  • RNA-Binding Proteins*
  • Sequence Homology, Nucleic Acid

Substances

  • DNA, Complementary
  • Peptide Initiation Factors
  • RNA, Messenger
  • RNA-Binding Proteins

Associated data

  • GENBANK/S72024
  • GENBANK/S72026
  • GENBANK/S72038