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    Science. 1995 Aug 4;269(5224):688-90.

    Molecular identification of an IgE-dependent histamine-releasing factor.

    MacDonald SM, Rafnar T, Langdon J, Lichtenstein LM.

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    Department of Medicine, Johns Hopkins University School of Medicine, Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA.

    Abstract

    An immunoglobulin E (IgE)-dependent histamine-releasing factor (HRF) produced by lymphocytes of atopic children and present in biological fluids of allergic patients has been identified and purified. Amino-terminal sequencing revealed extensive homology to a mouse protein, p21, and its human homolog, p23. Both recombinant proteins caused histamine release from the human basophils of a subpopulation of donors, and this release was dependent on IgE. Polyclonal antibodies recognized and removed the biological activity of recombinant and native HRF. HRF identifies a heterogeneity of IgE and is believed to play a prominent role in chronic allergic disease processes.

    PMID:
    7542803
    [PubMed - indexed for MEDLINE]

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