Your browser version may not work well with NCBI's Web applications. More information here...
1: Science. 1995 Jul 28;269(5223):496-512.Click here to read Links
Comment in:
Science. 1995 Jul 28;269(5223):468-70.
Science. 1995 Sep 29;269(5232):1805.
Science. 1996 Mar 1;271(5253):1302-3; author reply 1303-4.
Science. 1996 Mar 1;271(5253):1302; author reply 1303-4.

Whole-genome random sequencing and assembly of Haemophilus influenzae Rd.

Fleischmann RD, Adams MD, White O, Clayton RA, Kirkness EF, Kerlavage AR, Bult CJ, Tomb JF, Dougherty BA, Merrick JM, et al.

Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

An approach for genome analysis based on sequencing and assembly of unselected pieces of DNA from the whole chromosome has been applied to obtain the complete nucleotide sequence (1,830,137 base pairs) of the genome from the bacterium Haemophilus influenzae Rd. This approach eliminates the need for initial mapping efforts and is therefore applicable to the vast array of microbial species for which genome maps are unavailable. The H. influenzae Rd genome sequence (Genome Sequence DataBase accession number L42023) represents the only complete genome sequence from a free-living organism.

PMID: 7542800 [PubMed - indexed for MEDLINE]

Related Articles