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Int Arch Allergy Immunol. 1995 May-Jun;107(1-3):130-1.

Role of heat shock protein 65/60 in the pathogenesis of atherosclerosis.

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  • 1Institute for Biomedical Aging Research, Austrian Academy of Sciences, Innsbruck.


Investigations in rabbits and humans have provided experimental evidence that autoimmune reactions play a major role in the initial stages of the development of atherosclerosis. These involve the infiltration of the arterial intima with T cells reacting with heat shock protein (hsp) 65/60 and the occurrence of anti-hsp 65/60 antibodies. This early immunologically mediated stage of atherosclerosis is still reversible but if additional risk factors, such as high cholesterol levels, come into effect, severe mostly irreversible lesions develop.

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