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1: J Biol Chem. 1995 Jun 23;270(25):15187-93.Click here to read Links

Cyclophilin A and FKBP12 interact with YY1 and alter its transcriptional activity.

Yang WM, Inouye CJ, Seto E.

Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio 78245-3207, USA.

YY1 is a zinc finger transcription factor with unusual structural and functional features. In a yeast two-hybrid screen, two cellular proteins, cyclophilin A (CyPA) and FK506-binding protein 12 (FKBP12), interacted with YY1. These interactions are specific and also occur in mammalian cells. Cyclosporin A and FK506 efficiently disrupt the YY1-CyPA and YY1-FKBP12 interactions. Overexpression of human CyPA and FKBP12 have different effects on YY1-regulated transcription with these effects being promoter-dependent. These results suggest that immunophilins may be mediators in the functional role of YY1.

PMID: 7541038 [PubMed - indexed for MEDLINE]

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