Regulation of the interferon-induced PKR: can viruses cope?

M G Katze

doi:10.1016/s0966-842x(00)88880-0

Regulation of the interferon-induced PKR: can viruses cope?

Trends Microbiol. 1995 Feb;3(2):75-8. doi: 10.1016/s0966-842x(00)88880-0.

Author

M G Katze¹

Affiliation

¹ Dept of Microbiology, School of Medicine, University of Washington, Seattle 98195, USA.

PMID: 7537157
DOI: 10.1016/s0966-842x(00)88880-0

Abstract

Viruses that fail to block the lethal effects of the double-stranded-RNA-activated protein kinase (PKR) may be doomed; why do so many viruses go to so much trouble to downregulate this interferon-induced protein kinase? PKR may regulate cell growth and proliferation in uninfected cells, suggesting that it also participates in the antiproliferative arm of the interferon response.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cell Transformation, Neoplastic
Enzyme Induction
Gene Expression Regulation, Viral*
HSP40 Heat-Shock Proteins
Humans
Interferons / physiology*
Protein Serine-Threonine Kinases / antagonists & inhibitors
Protein Serine-Threonine Kinases / physiology*
Repressor Proteins / physiology
Virus Physiological Phenomena*
eIF-2 Kinase

Substances

DNAJC3 protein, human
HSP40 Heat-Shock Proteins
Repressor Proteins
Interferons
Protein Serine-Threonine Kinases
eIF-2 Kinase