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    Science. 1995 Mar 10;267(5203):1449-56.

    The Fas death factor.

    Nagata S, Golstein P.

    Osaka Bioscience Institute, Japan.

    Fas ligand (FasL), a cell surface molecule belonging to the tumor necrosis factor family, binds to its receptor Fas, thus inducing apoptosis of Fas-bearing cells. Various cells express Fas, whereas FasL is expressed predominantly in activated T cells. In the immune system, Fas and FasL are involved in down-regulation of immune reactions as well as in T cell-mediated cytotoxicity. Malfunction of the Fas system causes lymphoproliferative disorders and accelerates autoimmune diseases, whereas its exacerbation may cause tissue destruction.

    PMID: 7533326 [PubMed - indexed for MEDLINE]

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