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Science. 1995 Mar 10;267(5203):1449-56.

The Fas death factor.

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  • 1Osaka Bioscience Institute, Japan.

Abstract

Fas ligand (FasL), a cell surface molecule belonging to the tumor necrosis factor family, binds to its receptor Fas, thus inducing apoptosis of Fas-bearing cells. Various cells express Fas, whereas FasL is expressed predominantly in activated T cells. In the immune system, Fas and FasL are involved in down-regulation of immune reactions as well as in T cell-mediated cytotoxicity. Malfunction of the Fas system causes lymphoproliferative disorders and accelerates autoimmune diseases, whereas its exacerbation may cause tissue destruction.

PMID:
7533326
[PubMed - indexed for MEDLINE]
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