J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Feb 1;8(2):141-51.

Phase I/II evaluation of nevirapine alone and in combination with zidovudine for infection with human immunodeficiency virus.

Cheeseman SH, Havlir D, McLaughlin MM, Greenough TC, Sullivan JL, Hall D, Hattox SE, Spector SA, Stein DS, Myers M, et al.

Source

University of Massachusetts Medical School, Worcester.

Abstract

In these Phase I/II open-label clinical trials, 62 persons with human immunodeficiency virus type 1 (HIV-1) infection and CD4+ cell counts < 400/mm3 received nevirapine at doses of 12.5, 50, and 200 mg/day, alone or in combination with zidovudine, 200 mg q8h. Nevirapine was well tolerated in the doses tested. Mean steady-state trough levels were 0.23, 1.1, and 1.9 micrograms/ml for the 12.5, 50, and 200 mg/day doses, respectively. Early suppression of p24 antigen levels and increase in CD4+ cell count were reversed following rapid emergence of virus less susceptible to nevirapine. Resistant strains were isolated from all participants by 8 weeks. Nevertheless, reduction of p24 antigen levels to < 50% of baseline values persisted for 12 weeks or more in four of seven persons who received 200 mg nevirapine/day in combination with zidovudine: these individuals had been antigenemic on long-term zidovudine therapy. This study demonstrates a direct relationship between drug resistance and effects on surrogate markers in HIV-1 infection.

PMID:: 7530585; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Ovid Technologies, Inc.

Other Literature Sources

COS Scholar Universe

Medical

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Nevirapine, zidovudine, and didanosine compared with zidovudine and didanosine in patients with HIV-1 infection. A randomized, double-blind, placebo-controlled trial. National Institute of Allergy and Infectious Diseases AIDS Clinical Trials Group Protocol 241 Investigators. [Ann Intern Med. 1996]
Nevirapine, zidovudine, and didanosine compared with zidovudine and didanosine in patients with HIV-1 infection. A randomized, double-blind, placebo-controlled trial. National Institute of Allergy and Infectious Diseases AIDS Clinical Trials Group Protocol 241 Investigators.
D'Aquila RT, Hughes MD, Johnson VA, Fischl MA, Sommadossi JP, Liou SH, Timpone J, Myers M, Basgoz N, Niu M, et al. Ann Intern Med. 1996 Jun 15; 124(12):1019-30.
Alternating nevirapine and zidovudine treatment of human immunodeficiency virus type 1-infected persons does not prolong nevirapine activity. [J Infect Dis. 1994]
Alternating nevirapine and zidovudine treatment of human immunodeficiency virus type 1-infected persons does not prolong nevirapine activity.
de Jong MD, Loewenthal M, Boucher CA, van der Ende I, Hall D, Schipper P, Imrie A, Weigel HM, Kauffmann RH, Koster R. J Infect Dis. 1994 Jun; 169(6):1346-50.
Zidovudine and lamivudine: results of phase III studies. [J Acquir Immune Defic Syndr Hu...]
Zidovudine and lamivudine: results of phase III studies.
Staszewski S. J Acquir Immune Defic Syndr Hum Retrovirol. 1995; 10 Suppl 1:S57.
Review Current clinical experience with nevirapine for HIV infection. [Adv Exp Med Biol. 1996]
Review Current clinical experience with nevirapine for HIV infection.
Carr A, Cooper DA. Adv Exp Med Biol. 1996; 394:299-304.
Review Antiretrovirals for reducing the risk of mother-to-child transmission of HIV infection. [Cochrane Database Syst Rev. 2002]
Review Antiretrovirals for reducing the risk of mother-to-child transmission of HIV infection.
Brocklehurst P, Volmink J. Cochrane Database Syst Rev. 2002; (2):CD003510.

See reviews... See all...

Cited by 15 PubMed Central articles

Nevirapine induced Stevens-Johnson syndrome in an HIV infected patient. [Indian J Pharmacol. 2011]
Nevirapine induced Stevens-Johnson syndrome in an HIV infected patient.
Singh H, Kachhap VK, Kumar BN, Nayak K. Indian J Pharmacol. 2011 Feb; 43(1):84-6.
Review Combinatorial approaches to the prevention and treatment of HIV-1 infection. [Antimicrob Agents Chemother. 2...]
Review Combinatorial approaches to the prevention and treatment of HIV-1 infection.
Pirrone V, Thakkar N, Jacobson JM, Wigdahl B, Krebs FC. Antimicrob Agents Chemother. 2011 May; 55(5):1831-42. Epub 2011 Feb 22.
Implications of gender and pregnancy for antiretroviral drug dosing. [Curr Opin HIV AIDS. 2008]
Implications of gender and pregnancy for antiretroviral drug dosing.
Best BM, Capparelli EV. Curr Opin HIV AIDS. 2008 May; 3(3):277-82.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound
PubChem chemical compound records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records. Multiple substance records may contribute to the PubChem compound record.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance
PubChem chemical substance records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Phase I/II evaluation of nevirapine alone and in combination with zidovudine for...
Phase I/II evaluation of nevirapine alone and in combination with zidovudine for infection with human immunodeficiency virus.
J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Feb 1 ;8(2):141-51.

PubMed
RT-PCR assay for heme oxygenase-1 and heme oxygenase-2: a sensitive method to es...
RT-PCR assay for heme oxygenase-1 and heme oxygenase-2: a sensitive method to estimate cellular oxidative damage.
Ann N Y Acad Sci. 1994 Nov 17 ;738:427-30.

PubMed
Advanced diffuse non-Hodgkin's lymphoma. Analysis of prognostic factors by the i...
Advanced diffuse non-Hodgkin's lymphoma. Analysis of prognostic factors by the international index and by lactic dehydrogenase in an intergroup study.
Cancer. 1995 Feb 1 ;75(3):865-73.

PubMed
A family of ligands for the TNF receptor superfamily.
A family of ligands for the TNF receptor superfamily.
Stem Cells. 1994 Sep ;12(5):440-55.

PubMed
Hair growth-stimulating effects of cyclosporin A and FK506, potent immunosuppres...
Hair growth-stimulating effects of cyclosporin A and FK506, potent immunosuppressants.
J Dermatol Sci. 1994 Jul ;7 Suppl:S47-54.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: