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Nephrol Dial Transplant. 1994;9 Suppl 4:141-5.

Nephrotoxicity of immunosuppressive drugs.

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  • 1Division of Nephrology, Hypertension and Clinical Pharmacology, Oregon Health Sciences University, Portland 97201.

Abstract

Acute and chronic nephrotoxicity frequently limits the therapeutic benefits of immunosuppressive therapy for transplant and autoimmune indications. The clinical aspects, pathophysiology, and relevant pharmacology of current and future immunosuppressive drugs are reviewed in this paper. Insights gained from experimental models of chronic nephrotoxicity associated with tubulointerstitial fibrosis are presented.

PMID:
7528363
[PubMed - indexed for MEDLINE]
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