Abstract
The human AQP2 (collecting duct water channel, aquaporin 2) gene encodes a 271 amino acid protein and is a member of the MIP (major intrinsic protein of lens fiber) gene family. Using two-color fluorescence in situ hybridization on high-resolution R-banded chromosomes and human genomic DNA clones for AQP2 and MIP as probes, we found that both genes mapped closely within the human chromosome region 12q13.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Aquaporin 2
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Aquaporin 6
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Aquaporins*
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Bacterial Proteins / genetics*
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Cells, Cultured
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Chromosome Banding
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Chromosome Mapping
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Chromosomes, Human, Pair 12*
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Hominidae / genetics*
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Humans
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Immunophilins*
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In Situ Hybridization, Fluorescence / methods
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Ion Channels / genetics*
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Lymphocytes / cytology
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Lymphocytes / metabolism
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Membrane Proteins / genetics*
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Multigene Family*
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Peptidylprolyl Isomerase*
Substances
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AQP2 protein, human
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Aquaporin 2
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Aquaporin 6
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Aquaporins
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Bacterial Proteins
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Ion Channels
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Membrane Proteins
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Immunophilins
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Peptidylprolyl Isomerase