Human and mouse T-cell-receptor loci: the importance of comparative large-scale DNA sequence analyses

L Hood; B F Koop; L Rowen; K Wang

doi:10.1101/sqb.1993.058.01.040

Human and mouse T-cell-receptor loci: the importance of comparative large-scale DNA sequence analyses

Cold Spring Harb Symp Quant Biol. 1993:58:339-48. doi: 10.1101/sqb.1993.058.01.040.

Authors

L Hood¹, B F Koop, L Rowen, K Wang

Affiliation

¹ Department of Molecular Biotechnology, University of Washington, Seattle 98195.

PMID: 7525145
DOI: 10.1101/sqb.1993.058.01.040

Abstract

It is our belief that large-scale DNA sequencing will revolutionize the study of molecular biology, developmental biology, genetics, and evolution for the TCR gene families and, indeed, all multigene families. We also stress the power of comparative analyses for large-scale DNA sequencing efforts.

Publication types

Comparative Study
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Animals
Base Sequence
Biological Evolution
Chromosome Mapping
Conserved Sequence
DNA / genetics*
Genes, Regulator
Humans
Mice
Molecular Sequence Data
Multigene Family
Pseudogenes
RNA / genetics
Receptors, Antigen, T-Cell / genetics*
Sequence Analysis, DNA*
Sequence Homology, Nucleic Acid
Transcription, Genetic
Trypsinogen / genetics

Substances

Receptors, Antigen, T-Cell
RNA
Trypsinogen
DNA