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1: Hum Mol Genet. 1994 Jun;3(6):873-8.Click here to read Links

A mouse Y chromosome gene encoded by a region essential for spermatogenesis and expression of male-specific minor histocompatibility antigens.

Agulnik AI, Mitchell MJ, Lerner JL, Woods DR, Bishop CE.

Department of Obstetrics and Gynecology, University of Tennessee, Memphis 38103.

A new mouse Y chromosome gene, Smcy, has been isolated from the region encoding Spy, a spermatogenesis gene and Hya and Sdma, the genes that, respectively, control the expression of the male specific minor histocompatibility antigen H-Y, as measured by specific T-cell assays and the serologically detected male antigen SDMA. Smcy is well conserved on the Y in mouse, man and even marsupials. It is expressed in all adult male tissues tested and can also be detected during mouse development from as early as two cells. In addition, its human Y homologue, SMCY, is expressed in multiple tissues and maps to the same Yq deletion interval as the human H-Y antigen controlling locus, HY.

PMID: 7524912 [PubMed - indexed for MEDLINE]