Format

Send to:

Choose Destination
See comment in PubMed Commons below
Blood. 1994 Nov 15;84(10):3261-82.

Pivotal role of the B7:CD28 pathway in transplantation tolerance and tumor immunity.

Author information

  • 1Division of Hematologic Malignancies and Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115.

Abstract

The above story illustrates the translation of basic scientific discoveries to the clinic. In vitro and preclinical in vivo experimentation suggests that modulation of the B7:CD28 pathway will result in either amplification or suppression of the immune response. Considering the frequency with which diseases characterized by either inadequate or dysregulated immune function present to the practicing hematologist or oncologist, it is not difficult to envisage clinical applications for reagents that modulate this pathway. However, we still have much to learn about the function and clinical potential of this and other potentially redundant costimulatory pathways and therefore we suspect that this story will become considerably more complex over the next few years.

PMID:
7524733
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk