Praxis (Bern 1994). 1994 Oct 4;83(40):1106-10.

[Sodium valproate--current status of pharmacological research].

[Article in German]

Source

Department of Neurology, Institute of Psychiatry, London, England.

Abstract

Valproic acid has a wider antiepileptic spectrum than any other antiepileptic drug (AED) in clinical use. Valproate administration causes many neurochemical and neurophysiological alterations, including increased GABA levels, modified GABA turnover and release, decreased gamma-hydroxybutyrate synthesis and release, increased serotonin and dopamine release, decreased aspartate levels, reduction of repetitive firing of neurons, and possibly a reduction in calcium (T) currents; however, none of these effects have consistently and unequivocally been linked to the antiepileptic action of valproate.

PMID:: 7524125; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Review Basic pharmacology of valproate: a review after 35 years of clinical use for the treatment of epilepsy. [CNS Drugs. 2002]
Review Basic pharmacology of valproate: a review after 35 years of clinical use for the treatment of epilepsy.
Löscher W. CNS Drugs. 2002; 16(10):669-94.
Review Antiepileptic drug mechanisms of action. [Epilepsia. 1995]
Review Antiepileptic drug mechanisms of action.
Macdonald RL, Kelly KM. Epilepsia. 1995; 36 Suppl 2:S2-12.
Review Valproate and myoclonus. [Adv Neurol. 1986]
Review Valproate and myoclonus.
Chapman AG. Adv Neurol. 1986; 43:661-74.
Differential effects of vigabatrin, gamma-acetylenic GABA, aminooxyacetic acid, and valproate on levels of various amino acids in rat brain regions and plasma. [Naunyn Schmiedebergs Arch Phar...]
Differential effects of vigabatrin, gamma-acetylenic GABA, aminooxyacetic acid, and valproate on levels of various amino acids in rat brain regions and plasma.
Löscher W, Hörstermann D. Naunyn Schmiedebergs Arch Pharmacol. 1994 Mar; 349(3):270-8.
gamma-Hydroxybutyrate conversion into GABA induces displacement of GABAB binding that is blocked by valproate and ethosuximide. [J Pharmacol Exp Ther. 1997]
gamma-Hydroxybutyrate conversion into GABA induces displacement of GABAB binding that is blocked by valproate and ethosuximide.
Hechler V, Ratomponirina C, Maitre M. J Pharmacol Exp Ther. 1997 May; 281(2):753-60.

See reviews... See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.

Recent activity

Clear Turn Off Turn On

[Sodium valproate--current status of pharmacological research].
[Sodium valproate--current status of pharmacological research].
Praxis (Bern 1994). 1994 Oct 4 ;83(40):1106-10.

PubMed
Staining of amyloid precursor protein to study axonal damage in mild head injury...
Staining of amyloid precursor protein to study axonal damage in mild head injury.
Lancet. 1994 Oct 15 ;344(8929):1055-6.

PubMed
Diagnosis of prostatic carcinoma: the yield of serum prostate specific antigen, ...
Diagnosis of prostatic carcinoma: the yield of serum prostate specific antigen, digital rectal examination and transrectal ultrasonography.
J Urol. 1994 Nov ;152(5 Pt 1):1520-5.

PubMed
Fascination with 2-5A-dependent RNase: a unique enzyme that functions in interfe...
Fascination with 2-5A-dependent RNase: a unique enzyme that functions in interferon action.
J Interferon Res. 1994 Jun ;14(3):101-4.

PubMed
Intracellular turnover of cystic fibrosis transmembrane conductance regulator. I...
Intracellular turnover of cystic fibrosis transmembrane conductance regulator. Inefficient processing and rapid degradation of wild-type and mutant proteins.
J Biol Chem. 1994 Oct 14 ;269(41):25710-8.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: