A G protein involved in nucleocytoplasmic transpor...[Trends Biochem Sci. 1994]

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1: Trends Biochem Sci. 1994 May;19(5):211-6.Links

A G protein involved in nucleocytoplasmic transport: the role of Ran.

Moore MS, Blobel G.

Rockefeller University, Howard Hughes Medical Institute, New York, NY 10021.

Ran is the only known member of the Ras superfamily of small GTP-binding proteins to be localized primarily inside the nucleus. Recently, Ran was unexpectedly identified as one of the soluble factors required for nuclear import. As this protein has also been implicated in RNA export, nuclear import and export may be more closely related than previously thought, with Ran playing a key role in each.

PMID: 7519373 [PubMed - indexed for MEDLINE]

ReviewFunctions of the GTPase Ran in RNA export from the nucleus.
Curr Opin Cell Biol. 1998 Jun; 10(3):400-8.

[Curr Opin Cell Biol. 1998]
In vitro and in vivo evidence that protein and U1 snRNP nuclear import in somatic cells differ in their requirement for GTP-hydrolysis, Ran/TC4 and RCC1.
Nucleic Acids Res. 1996 May 15; 24(10):1829-36.

[Nucleic Acids Res. 1996]
ReviewA new role of ran GTPase.
Biochem Biophys Res Commun. 1999 Sep 7; 262(3):571-4.

[Biochem Biophys Res Commun. 1999]
The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus.
EMBO J. 1997 Nov 3; 16(21):6535-47.

[EMBO J. 1997]
Inhibition of nuclear protein import by nonhydrolyzable analogues of GTP and identification of the small GTPase Ran/TC4 as an essential transport factor.
J Cell Biol. 1993 Dec; 123(6 Pt 2):1649-59.

[J Cell Biol. 1993]
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Cited by 34 PubMed Central articles

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NXT2 is required for embryonic heart development in zebrafish.
Huang H, Zhang B, Hartenstein PA, Chen JN, Lin S. BMC Dev Biol. 2005 Mar 24; 5:7. Epub 2005 Mar 24.

[BMC Dev Biol. 2005]
Saccharomyces cerevisiae putative G protein, Gtr1p, which forms complexes with itself and a novel protein designated as Gtr2p, negatively regulates the Ran/Gsp1p G protein cycle through Gtr2p.
Nakashima N, Noguchi E, Nishimoto T. Genetics. 1999 Jul; 152(3):853-67.

[Genetics. 1999]
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Cited by 34 PubMed Central articles

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