Beta 2-microglobulin-independent MHC class Ib mole...[Science. 1994]

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1: Science. 1994 Jul 8;265(5169):259-62. Links

Beta 2-microglobulin-independent MHC class Ib molecule expressed by human intestinal epithelium.

Balk SP, Burke S, Polischuk JE, Frantz ME, Yang L, Porcelli S, Colgan SP, Blumberg RS.

Hematology-Oncology Division, Beth Israel Hospital, Harvard Medical School, Boston, MA 02215.

A major histocompatibility complex class Ib protein, CD1d, is expressed by human intestinal epithelial cells (IECs) and is a ligand for CD8+ T cells. CD1d was found to be expressed on the surface of human IECs as a 37-kilodalton protein that was beta 2-microglobulin (beta 2M) independent with no N-linked carbohydrate. Transfection into a beta 2M- cell line confirmed that CD1d could be expressed at the cell surface in the absence of beta 2M. These data indicate that IECs use a specialized pathway for CD1d synthesis and that a beta 2M-independent class Ib protein may be the normal ligand for some intestinal T cells.

PMID: 7517575 [PubMed - indexed for MEDLINE]

Delineation of a CD1d-restricted antigen presentation pathway associated with human and mouse intestinal epithelial cells.
Gastroenterology. 2003 May; 124(5):1420-31.

[Gastroenterology. 2003]
Expression of a nonpolymorphic MHC class I-like molecule, CD1D, by human intestinal epithelial cells.
J Immunol. 1991 Oct 15; 147(8):2518-24.

[J Immunol. 1991]
Characterization of CD1d in mucosal immune function: an immunotherapeutic target for inflammatory bowel disease.
Keio J Med. 2001 Mar; 50(1):39-44.

[Keio J Med. 2001]
ReviewIntraepithelial lymphocytes and their recognition of non-classical MHC molecules.
Int Rev Immunol. 1994; 11(1):15-30.

[Int Rev Immunol. 1994]
ReviewStructure and function of the CD1 family of MHC-like cell surface proteins.
Immunol Rev. 1995 Oct; 147:5-29.

[Immunol Rev. 1995]
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Cited by 21 PubMed Central articles

Cd1d-dependent regulation of bacterial colonization in the intestine of mice.
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The mucosal immune response to laryngopharyngeal reflux.
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[Am J Respir Crit Care Med. 2008]
Intestinal heat shock protein 110 regulates expression of CD1d on intestinal epithelial cells.
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[J Clin Invest. 2003]
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