Genes Chromosomes Cancer. 1994 Feb;9(2):145-7.

Band 11q13 is nonrandomly rearranged in hibernomas.

Source

Cytogenetics Research Laboratory, Roswell Park Cancer Institute, Buffalo, New York 14263.

Abstract

Cytogenetic study of a short-term culture from a hibernoma, a very rare benign proliferation of the brown fat, demonstrated a four-break translocation t(5;7;11;17)(p14;q11.23;q13.1-13.3;p11.2) as the sole abnormality in all analyzed cells. Complex translocation involving band 11q13 have also been detected in the two other published cases of hibernoma. The consistent finding of 11q13 rearrangements appears to distinguish hibernoma from other benign adipose tissue tumors cytogenetically and suggests that 11q13 changes may play an important role in hibernoma pathogenesis.

PMID:: 7513546; [PubMed - indexed for MEDLINE]

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Chromosome changes in a case of hibernoma. [Genes Chromosomes Cancer. 1992]
Chromosome changes in a case of hibernoma.
Dal Cin P, Van Damme B, Hoogmartens M, Van Den Berghe H. Genes Chromosomes Cancer. 1992 Sep; 5(2):178-80.
11q13 alterations in two cases of hibernoma: large heterozygous deletions and rearrangement breakpoints near GARP in 11q13.5. [Genes Chromosomes Cancer. 2003]
11q13 alterations in two cases of hibernoma: large heterozygous deletions and rearrangement breakpoints near GARP in 11q13.5.
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Hibernomas are characterized by rearrangements of chromosome bands 11q13-21. [Int J Cancer. 1994]
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Review The role of cytogenetics in the classification of soft tissue tumours. [Virchows Arch. 1997]
Review The role of cytogenetics in the classification of soft tissue tumours.
Dei Tos AP, Dal Cin P. Virchows Arch. 1997 Aug; 431(2):83-94.
Review [From cytogenetics to cytogenomics of adipose tissue tumors: 1. Benign adipose tissue tumors]. [Bull Cancer. 2002]
Review [From cytogenetics to cytogenomics of adipose tissue tumors: 1. Benign adipose tissue tumors].
Pedeutour F, Foa C. Bull Cancer. 2002 Jul-Aug; 89(7-8):689-95.

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Cited by 1 PubMed Central article

Hibernomas are characterized by homozygous deletions in the multiple endocrine neoplasia type I region. Metaphase fluorescence in situ hybridization reveals complex rearrangements not detected by conventional cytogenetics. [Am J Pathol. 1999]
Hibernomas are characterized by homozygous deletions in the multiple endocrine neoplasia type I region. Metaphase fluorescence in situ hybridization reveals complex rearrangements not detected by conventional cytogenetics.
Gisselsson D, Höglund M, Mertens F, Dal Cin P, Mandahl N. Am J Pathol. 1999 Jul; 155(1):61-6.

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