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Tyrosine kinase JAK1 is associated with the granulocyte-colony-stimulating factor receptor and both become tyrosine-phosphorylated after receptor activation.
Melbourne Tumour Biology Branch, Ludwig Institute for Cancer Research, Victoria, Australia.
Granulocyte-colony-stimulating factor (G-CSF) stimulates the proliferation and differentiation of cells of the neutrophil lineage by interaction with a specific receptor. Early signal transduction events following G-CSF receptor activation were studied. We detected tyrosine phosphorylation of both the G-CSF receptor and the protein tyrosine kinase JAK1 following G-CSF binding to the human G-CSF receptor. In vitro, the kinase activity of JAK1 was increased by G-CSF stimulation. Coimmunoprecipitation of JAK1 with the G-CSF receptor suggested a physical association which existed prior to G-CSF stimulation.
PMID: 7512720 [PubMed - indexed for MEDLINE]
PMCID: PMC43499
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Cited by 7 PubMed Central articles
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Novel point mutation in the extracellular domain of the granulocyte colony-stimulating factor (G-CSF) receptor in a case of severe congenital neutropenia hyporesponsive to G-CSF treatment.
Ward AC, van Aesch YM, Gits J, Schelen AM, de Koning JP, van Leeuwen D, Freedman MH, Touw IP.
J Exp Med. 1999 Aug 16; 190(4):497-507.
[J Exp Med. 1999]
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Sustained receptor activation and hyperproliferation in response to granulocyte colony-stimulating factor (G-CSF) in mice with a severe congenital neutropenia/acute myeloid leukemia-derived mutation in the G-CSF receptor gene.
Hermans MH, Antonissen C, Ward AC, Mayen AE, Ploemacher RE, Touw IP.
J Exp Med. 1999 Feb 15; 189(4):683-92.
[J Exp Med. 1999]
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Tyrosine 763 of the murine granulocyte colony-stimulating factor receptor mediates Ras-dependent activation of the JNK/SAPK mitogen-activated protein kinase pathway.
Rausch O, Marshall CJ.
Mol Cell Biol. 1997 Mar; 17(3):1170-9.
[Mol Cell Biol. 1997]
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