Spinal co-administration of peptide substance P antagonist increases antinociceptive effect of the opioid peptide biphalin

K Misterek; I Maszczynska; A Dorociak; S W Gumulka; D B Carr; S K Szyfelbein; A W Lipkowski

doi:10.1016/0024-3205(94)00494-3

Spinal co-administration of peptide substance P antagonist increases antinociceptive effect of the opioid peptide biphalin

Life Sci. 1994;54(14):939-44. doi: 10.1016/0024-3205(94)00494-3.

Authors

K Misterek¹, I Maszczynska, A Dorociak, S W Gumulka, D B Carr, S K Szyfelbein, A W Lipkowski

Affiliation

¹ Department of Pharmacodynamics, Medical Academy, Warsaw, Poland.

PMID: 7511201
DOI: 10.1016/0024-3205(94)00494-3

Abstract

Intrathecal injection of 0.25 micrograms of undecapeptide substance P antagonist (SPA) produced transient antinociception with a peak effect at 5 min. Increasing the SPA dose resulted in neurotoxicity. Intrathecal injection of the opioid peptide biphalin (BIP) produced antinociception for over 3 hrs without neurotoxicity. Co-administration of SPA (at subtoxic doses) increased BIP's antinociceptive effect. Naltrexone reversed analgesia due to BIP alone as well as after BIP+SPA.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Analgesics / administration & dosage*
Analgesics / pharmacology
Animals
Drug Synergism
Enkephalins / administration & dosage*
Enkephalins / pharmacology
Injections, Spinal
Male
Naltrexone / pharmacology
Pain / drug therapy*
Pain Measurement
Rats
Rats, Wistar
Substance P / administration & dosage
Substance P / analogs & derivatives*
Substance P / antagonists & inhibitors
Substance P / pharmacology

Substances

Analgesics
Enkephalins
Substance P
Naltrexone
substance P, prolyl(2)-tryptophan(7,9)-
biphalin