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J Immunol. 1994 Feb 15;152(4):1751-5.

Fas antigen and p55 TNF receptor signal apoptosis through distinct pathways.

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  • 1Department of Cardiovascular Research, Genentech, Inc., South San Francisco, CA 94080.


The Fas Ag and the p55 TNF receptor (TNF-R1) are related molecules that can signal apoptosis. Some tumor cell lines are selectively killed by Fas activation and others by TNF-R1 activation even though both receptors are often co-expressed. TNF-R1-mediated cytotoxicity can be selectively inhibited under conditions in which Fas-mediated cell death is not affected. Activation of both receptors results in synergistic signaling of apoptosis. These results indicate that different biochemical pathways are activated by Fas and TNF-R1. Combination treatment with agonists of Fas and TNF-R1 may have therapeutic potential.

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