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1: J Biol Chem. 1995 Nov 17;270(46):27411-4. Links

Molecular cloning and functional expression of a novel amiloride-sensitive Na+ channel.

Waldmann R, Champigny G, Bassilana F, Voilley N, Lazdunski M.

Institut de Pharmacologie Moléculaire et Cellulaire, Valbonne, France.

We have isolated a cDNA for a novel human amiloride-sensitive Na+ channel isoform (called delta) which is expressed mainly in brain, pancreas, testis, and ovary. When expressed in Xenopus oocytes, it generates an amiloride-sensitive Na+ channel with biophysical and pharmacological properties distinct from those of the epithelial Na+ channel, a multimeric assembly of alpha, beta, and gamma subunits. The Na+ current produced by the new delta isoform is increased by two orders of magnitude after coexpression of the beta and gamma subunit of the epithelial Na+ channel showing that delta can associate with other subunits and is part of a novel multisubunit ion channel.

PMID: 7499195 [PubMed - indexed for MEDLINE]

Novel isoforms of the beta and gamma subunits of the Xenopus epithelial Na channel provide information about the amiloride binding site and extracellular sodium sensing.
Proc Natl Acad Sci U S A. 1997 May 27; 94(11):5949-54.

[Proc Natl Acad Sci U S A. 1997]
Molecular cloning, functional expression and chromosomal localization of an amiloride-sensitive Na(+) channel from human small intestine.
FEBS Lett. 2000 Apr 14; 471(2-3):205-10.

[FEBS Lett. 2000]
Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits.
Nature. 1994 Feb 3; 367(6462):463-7.

[Nature. 1994]
ReviewMolecular biology of the amiloride-sensitive epithelial Na+ channel.
Exp Physiol. 1996 May; 81(3):483-92.

[Exp Physiol. 1996]
ReviewThe amiloride-blockable sodium channel of epithelial tissue.
Ion Channels. 1988; 1:251-82.

[Ion Channels. 1988]
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